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          焦點新聞

          何春江教授團隊解析年齡相關的免疫和基因表達變化

          發布日期:2021-07-29 發表者:陳治國 瀏覽次數:


          圖1. ADEIP的界面和開發流程


             南湖新聞網訊(通訊員|陳文博  審核人|何春江)近日,Briefings in Bioinformatics 在線發表了信息學院、生物醫學與健康學院何春江課題組最新研究成果,該研究搭建了一個平臺ADEIP,用于展示和檢索年齡相關的基因表達和免疫圖譜。


             ADEIP包括來自GTEx計劃中30個主要人體組織超過16000個樣本的基因表達數據,這些樣本來的年齡范圍在20-80歲之間的捐贈者。該研究對不同年齡組的差異表達基因和基因集、免疫相關基因和免疫細胞組成等幾個方面進行了整合分析。同時對已知與SARS-CoV-2和人類間充質干細胞(hMSC)相關的基因進行了舉例分析,展示了ADEIP的相關應用。作為一個比較全面的平臺,ADEIP可用于研究與衰老相關的表達和跨組織的免疫地圖,有助于了解與年齡相關的傳染病或遺傳疾病的機制,從而開發個性化的治療方案。


             信息學院研究生劉旋和武漢大學基礎醫學院陳文博為該論文共同第一作者,信息學院、生物醫學與健康學院何春江教授,德州農工大學韓冷教授和華中農業大學生物醫學與健康學院董志強教授為共同通訊作者,信息學院章文教授參與研究。


          英文摘要:


          Gene expression and immune status in human tissues are changed with aging. There is a need to develop a comprehensive platform to explore the dynamics of age-related gene expression and immune profiles across tissues in genome-wide studies. Here, we collected RNA-Seq datasets from GTEx project, containing 16?704 samples from 30 major tissues in six age groups ranging from 20 to 79 years old. Dynamic gene expression along with aging were depicted and gene set enrichment analysis was performed among those age groups. Genes from 34 known immune function categories and immune cell compositions were investigated and compared among different age groups. Finally, we integrated all the results and developed a platform named ADEIP (http://gb.whu.edu.cn/ADEIP or http://geneyun.net/ADEIP), integrating the age-dependent gene expression and immune profiles across tissues. To demonstrate the usage of ADEIP, we applied two datasets: severe acute respiratory syndrome coronavirus 2 and human mesenchymal stem cells-assoicated genes. We also included the expression and immune dynamics of these genes in the platform. Collectively, ADEIP is a powerful platform for studying age-related immune regulation in organogenesis and other infectious or genetic diseases.


          全文鏈接:

          https://academic.oup.com/bib/advance-article/doi/10.1093/bib/bbab274/6319933

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